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GINSENOSIDE RB2

ginsenoside rb2

CAS: 11021-13-9

Molecular Formula: C53H90O22

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GINSENOSIDE RB2 - Names and Identifiers

Name ginsenoside rb2
Synonyms NSC 308878
Ginsenoside C
GINSENOSIDE RB2
ginsenoside rb2
-d-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl2-o-beta-d-glucopyranosyl-
beta-d-glucopyranoside,(3-beta,12-beta)-20-((6-o-alpha-l-arabinopyranosyl-beta
12-hydroxy-20-[(6-O-pentopyranosylhexopyranosyl)oxy]dammar-24-en-3-yl 2-O-hexopyranosylhexopyranoside
(3beta,12beta)-12-hydroxy-20-[(6-O-pentopyranosylhexopyranosyl)oxy]dammar-24-en-3-yl 2-O-hexopyranosylhexopyranoside
(3β,12β)-20-[(6-O-α-L-Arabinopyranosyl-β-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
b-D-Glucopyranoside, (3b,12b)-20-[(6-O-a-L-arabinopyranosyl-b-D-glucopyranosyl)oxy]-12-hydroxydammar-24-en-3-yl2-O-b-D-glucopyranosyl-
20-((6-O-alpha-L-Arabinopyranosyl-beta-D-glucopyranosyl)oxy)-12beta-hydroxydammar-24-en-3beta-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
beta-D-Glucopyranoside, (3-beta,12-beta)-20-((6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy)-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-
(3beta,12beta)-20-{[(3xi)-6-O-(alpha-L-arabinopyranosyl)-beta-D-ribo-hexopyranosyl]oxy}-12-hydroxydammar-24-en-3-yl 2-O-beta-D-glucopyranosyl-beta-D-glucopyranoside
CAS 11021-13-9
EINECS 234-251-4
InChI InChI=1/C53H90O22/c1-23(2)10-9-14-53(8,75-47-43(67)39(63)37(61)29(72-47)22-69-45-41(65)34(58)26(57)21-68-45)24-11-16-52(7)33(24)25(56)18-31-50(5)15-13-32(49(3,4)30(50)12-17-51(31,52)6)73-48-44(40(64)36(60)28(20-55)71-48)74-46-42(66)38(62)35(59)27(19-54)70-46/h10,24-48,54-67H,9,11-22H2,1-8H3/t24-,25+,26-,27+,28+,29+,30-,31+,32-,33-,34-,35+,36+,37+,38-,39?,40-,41+,42+,43+,44+,45-,46-,47-,48-,50-,51+,52+,53-/m0/s1

GINSENOSIDE RB2 - Physico-chemical Properties

Molecular FormulaC53H90O22
Molar Mass1079.27
Density1.42±0.1 g/cm3(Predicted)
Melting Point197～199℃
Boling Point1117.1±65.0 °C(Predicted)
Specific Rotation(α)（c0.98，methanol）+3.05°
Flash Point629.4°C
Solubility H2O : ≥ 100 mg/mL (92.66 mM);DMSO : 9.5 mg/mL (8.80 mM; Need ultrasonic and warming)
Vapor Presure0mmHg at 25°C
AppearanceWhite powder (ethanol-butanol 1:5)
ColorWhite to Off-White
pKa12.85±0.70(Predicted)
Storage ConditionSealed in dry,2-8°C
StabilityHygroscopic
SensitiveEasily absorbing moisture
Refractive Index1.621
MDLMFCD00221755
Physical and Chemical PropertiesRoot of Panax ginseng C.A.Mey.

GINSENOSIDE RB2 - Risk and Safety

Risk Codes22 - Harmful if swallowed
Safety DescriptionS45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.)
S24/25 - Avoid contact with skin and eyes.
WGK Germany3
RTECSLZ5779240
HS Code29389090

GINSENOSIDE RB2 - Reference

Reference
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1. Li Xiao, Qingtian, Yajuan, Du Juan, etc Determination of 7 kinds of ginsenosides in ginseng flowers by one assay and multiple evaluations [J] Chinese herbal medicine 2019 v.50; No.659 (24): 213-217.
2. Zhang Chuyu, Chen Suhong and Wu Suxiang Determination of 8 kinds of glycosides in Compound Ginseng Tablets by one test and multiple evaluation method [J] China Modern Applied Pharmacy 2018 35 (05): 90-96.
3. Hong Yilian, Gu Xuejiang, Xu Jing, etc Effect of ginsenoside Rb2 on liver lipid metabolism in mice with hyperlipidemic fatty liver and its mechanism [J] Journal of Wenzhou Medical College 2018 048 (005): 338-341 349.
4. Miao Rui, Wu Dongxue, Wang Qiuying, etc Rapid separation of ginsenosides based on multi walled carbon nanotubes [J] Journal of Chemistry of Colleges and Universities, 2018.
5. Zhao Changling, Yang Shengchao, Chen Zhongjian, et al Total anthocyanin and total saponin content and saponin monomer composition of purple and green Panax notoginseng [J] Traditional Chinese Medicine, 2014, 37 (10): 1749-1753.
6. Xu Canhui, He Weiwei Determination of seven ginsenosides in American ginseng health food by HPLC [J] Food and Drug, 2015, 17 (004): 273-277.
7. Yu Jian, Xu Xiaozhen, Gu Liqiang, et al Simultaneous Determination of 9 Saponins in Shenmai Injection by High Performance Liquid Chromatography Tandem Mass Spectrometry [J] Chinese Journal of Traditional Chinese Medicine, 2014.
8. Yang Lin, Xu Xiaozhen, Chen Jinbai, et al Simultaneous Determination of 8 Ginsenosides in Shenmai Injection by HPLC [J] Chinese patent medicine, 2019.
9. Xia Wanxia, Zhang Shangwei, Ge Yazhong, et al Transformation of ginsenoside by lactic acid bacteria [J] Modern Food Science and Technology, 2018, 34 (09): 136-142.
10. Wang Ke, Hu Huiling, Xu Ying, Ding Rui, Wang Ying, Duan Chaohui. Study on the therapeutic effect and mechanism of ginsenoside Rb2 on nonalcoholic fatty liver disease in mice [J]. Journal of Tropical Medicine, 2021,21 (02): 125-129+143+120.
11. Wang Yan, Wei Zhongxian, Li Jing. Determination of ginsenoside content in Zhenyuan tablets from different manufacturers by HPLC [J]. Journal of Northwest Pharmacy, 2020, 35 (05): 669-673.
12. Wen Baoqing, Li Wenqing, Zhou Miaoxia, Lin Kunxia, Wang Xiaodong, Qian Zhengming. Identification and analysis of chemical components in Fushen Yin by core-shell chromatography quadrupole time-of-flight mass spectrometry [J]. Shizhen National Medicine and Traditional Chinese Medicine, 2020,31 (06): 1334-1338.
13. Zhang Na, Huang Xin, Guo Yunlong, Yue Hao, Liu Shuying. Research on the distribution of ginsenosides in different habitats based on UPLC-QQQ-MS multi index statistical analysis [J]. Specialty Research, 2020,42 (06): 48-54.
14. Shao Zijun, Li Zhiman, Yu Pengcheng, Chen Jianbo, Li Shanshan, Sun Yinshi. The effect of amino acid transformation of rare ginsenosides in Panax notoginseng flowers and its extract on lipopolysaccharide induced RAW264.7 cell activity [J]. Chinese Herbal Medicine, 2021,52 (03): 702-710
15. Dai, Shanshan, et al. "Ginsenoside Rb2 promotes glucose metabolism and attenuates fat accumulation via AKT-dependent mechanisms." Biomedicine & Pharmacotherapy 100 (2018): 93-100.https://doi.org/10.1016/j.biopha.2018.01.111
16. Lin, Yi, et al. "Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis." Adipocyte 9.1 (2020): 302-312.https://doi.org/10.1080/21623945.2020.1778826
17. Hong, Yilian, et al. "Ginsenoside Rb2 alleviates obesity by activation of brown fat and induction of browning of white fat." Frontiers in endocrinology 10 (2019): 153.https://doi.org/10.3389/fendo.2019.00153
18. Manying Wang, Jixiang Ren, Xuenan Chen, Jianzeng Liu, Xiaohao Xu, Xiangyan Li, Daqing Zhao, Liwei Sun, 20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway, Biochemical Ph
19. Zhengming Qian, Qi Huang, Chunhong Li, Jing Chen, Gang Li, Hongyan Ma & Juying Xie (2020) Analysis of ginseng root and leaf by multiple columns and detections liquid chromatography, Journal of Liquid Chromatography & Related Technologies, 43:13-14, 464-473
20. Jin, Wenqi, et al. "Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells." Life sciences 245 (2020): 117337.https://doi.org/10.1016/j.lfs.2020.117337
21. Joo, Kyung-Mi, et al. "Pharmacokinetic study of ginsenoside Re with pure ginsenoside Re and ginseng berry extracts in mouse using ultra performance liquid chromatography/mass spectrometric method." Journal of pharmaceutical and biomedical analysis 51.1 (20
22. [IF=6.06] Jiahong Han et al."Compatibility effects of ginseng and Ligustrum lucidum Ait herb pair on hematopoietic recovery in mice with cyclophosphamide-induced myelosuppression and its material basis."J Ginseng Res. 2020 Mar;44:291
23. [IF=6.06] Yang Xiu et al."Simultaneous determination and difference evaluation of 14 ginsenosides in Panax ginseng roots cultivated in different areas and ages by high-performance liquid chromatography coupled with triple quadrupole mass spectrometer in the multipl
24. [IF=5.34] Shan-Shan Zhou et al."Stronger anti-obesity effect of white ginseng over red ginseng and the potential mechanisms involving chemically structural/compositional specificity to gut microbiota."Phytomedicine. 2020 Aug;74:152761
25. [IF=4.545] Shanshan Dai et al."Ginsenoside Rb2 promotes glucose metabolism and attenuates fat accumulation via AKT-dependent mechanisms."Biomed Pharmacother. 2018 Apr;100:93
26. [IF=4.36] Bin Ma et al."Sulfur fumigation reducing systemic exposure of ginsenosides and weakening immunomodulatory activity of ginseng."J Ethnopharmacol. 2017 Jan;195:222
27. [IF=3.935] Hong Zhang et al."A multidimensional analytical approach based on time-decoupled online comprehensive two-dimensional liquid chromatography coupled with ion mobility quadrupole time-of-flight mass spectrometry for the analysis of ginsenosides from white a
28. [IF=3.935] Shan-Shan Zhou et al."Synchronous characterization of carbohydrates and ginsenosides yields deeper insights into the processing chemistry of ginseng."J Pharmaceut Biomed. 2017 Oct;145:59
29. [IF=3.644] Hong Yilian et al."Ginsenoside Rb2 Alleviates Obesity by Activation of Brown Fat and Induction of Browning of White Fat."Front Endocrinol. 2019 Mar;0:153
30. [IF=6.558] Qingqing Song et al."Binary code, a flexible tool for diagnostic metabolite sequencing of medicinal plants."Anal Chim Acta. 2019 Dec;1088:89
31. [IF=6.06] Zhenzhuo Li et al."Ginsenosides repair UVB-induced skin barrier damage in BALB/c hairless mice and HaCaT keratinocytes."J Ginseng Res. 2021 May;:
32. [IF=5.878] Jianbo Chen et al."Protection by ginseng saponins against cyclophosphamide-induced liver injuries in rats by induction of cytochrome P450 expression and mediation of the l-arginine/nitric oxide pathway based on metabolomics."Phytother Res. 2021 Jun;35(6):
33. [IF=5.396] Hui Wang et al."Ginsenoside extract from ginseng extends lifespan and health span in Caenorhabditis elegans."Food Funct. 2021 Aug;12(15):6793-6808
34. [IF=5.34] You-Ping Wu et al."Evidences for the mechanism of Shenmai injection antagonizing doxorubicin-induced cardiotoxicity."Phytomedicine. 2021 Jul;88:153597
35. [IF=4.96] Manying Wang et al."20(S)-ginsenoside Rg3 promotes myoblast differentiation and protects against myotube atrophy via regulation of the Akt/mTOR/FoxO3 pathway."Biochem Pharmacol. 2020 Oct;180:114145
36. [IF=4.411] Jianbo Chen et al."Neuroprotective Effects of Red Ginseng Saponins in Scopolamine-Treated Rats and Activity Screening Based on Pharmacokinetics."Molecules. 2019 Jan;24(11):2136
37. [IF=4.142] Wang Chenxi et al."Rapid discovery of potential ADR compounds from injection of total saponins from Panax notoginseng using data-independent acquisition untargeted metabolomics."Analytical And Bioanalytical Chemistry. 2021 Oct 26
38. [IF=3.935] Ruimei Lin et al."Global identification and determination of the major constituents in Kai-Xin-San by ultra-performance liquid chromatography-quadrupole-Orbitrap mass spectrometry and gas chromatography-mass spectrometry."J Pharmaceut Biomed. 2021 Nov;206
39. [IF=3.659] Zhang Sheng et al."Protective effect of Shenmai injection on doxorubicin-induced cardiotoxicity via regulation of inflammatory mediators."Bmc Complem Altern M. 2019 Dec;19(1):1-10
40. [IF=3.647] Wenqi Jin et al."Ginsenoside Rd attenuates ACTH-induced corticosterone secretion by blocking the MC2R-cAMP/PKA/CREB pathway in Y1 mouse adrenocortical cells."Life Sci. 2020 Mar;245:117337
41. [IF=3.645] Mengmeng Jia et al."UHPLC coupled with mass spectrometry and chemometric analysis of Kang-Ai injection based on the chemical characterization, simultaneous quantification, and relative quantification of 47 herbal alkaloids and saponins."J Sep Sci. 2020 Ju
42. [IF=3.361] Yuhao Zhang et al."An integrated approach for structural characterization of Gui Ling Ji by traveling wave ion mobility mass spectrometry and molecular network."Rsc Adv. 2021 Apr;11(26):15546-15556
43. [IF=3.146] Yi Lin et al."Ginsenoside Rb2 improves insulin resistance by inhibiting adipocyte pyroptosis."Adipocyte. 2020;9(1):302-312
44. [IF=2.629] Zhang Meiyu et al."In Vitro Transformation of Protopanaxadiol Saponins in Human Intestinal Flora and Its Effect on Intestinal Flora."Evid-Based Compl Alt. 2021;2021:1735803
45. [IF=2.408] Fang-Tong Li et al."In Vitro Effects of Ginseng and the Seed of Zizyphus jujuba var. spinosa on Gut Microbiota of Rats with Spleen Deficiency."Chem Biodivers. 2020 Sep;17(9):e2000199
46. [IF=1.934] Zhang Chen et al."Biotransformation of ginsenoside Rc to Rd by endophytic bacterium Bacillus sp. G9y isolated from Panax quinquefolius."Anton Leeuw Int J G. 2021 Apr;114(4):437-444
47. [IF=1.312] Zhengming Qian et al."Analysis of ginseng root and leaf by multiple columns and detections liquid chromatography."Journal Of Liquid Chromatography & Related Technologies. 2020 Mar 02
48. [IF=2.419] Yinping Jin et al."Dynamic changes of ginsenosides in Panax quinquefolius fruit at different development stages measured by UHPLC-Orbitrap MS."Rapid Communications In Mass Spectrometry. 2022 Feb 17
49. [IF=6.06] Qingxia Huang et al."Major ginsenosides from Panax ginseng promote aerobic cellular respiration and SIRT1-mediated mitochondrial biosynthesis in cardiomyocytes and neurons."J Ginseng Res. 2022 Feb;:
50. [IF=7.514] Di Qu et al."Sediment formation and analysis of the main chemical components of aqueous extracts from different parts of ginseng roots."Food Chem. 2022 Jan;:132146
51. [IF=5.811] He Zhang et al."Prevention Effect of Protopanaxadiol-Type Saponins Saponins and Protopanaxatriol-Type Saponins on Myelosuppression Mice Induced by Cyclophosphamide.."Frontiers in Pharmacology. 2022 Apr;13:845034-845034
52. [IF=4.35] Di Qu et al."Analysis of Key Chemical Components in Aqueous Extract Sediments of Panax Ginseng at Different Ages."Foods. 2022 Jan;11(8):1161
53. [IF=6.558] Yan Cao et al."Widely quasi-quantitative analysis enables temporal bile acids-targeted metabolomics in rat after oral administration of ursodeoxycholic acid."ANALYTICA CHIMICA ACTA. 2022 Jun;1212:339885
54. [IF=6.576] Zhi-man Li et al."Transformation Mechanism of Rare Ginsenosides in American Ginseng by Different Processing Methods and Antitumour Effects."Frontiers in Nutrition. 2022; 9: 833859
55. [IF=6.576] Rensong Huang et al."Studies on Bioactive Components of Red Ginseng by UHPLC-MS and Its Effect on Lipid Metabolism of Type 2 Diabetes Mellitus."Frontiers in Nutrition. 2022; 9: 865070
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